Current Issue : July-September Volume : 2018 Issue Number : 3 Articles : 3 Articles
To investigate the gastroprotective activity ethanolic extract leaves of Acmella oppositifolia (A. oppositifolia) in different experimental models of gastric ulcer in rats. The ethanolic extract leaves of Acmella oppositifolia were studied at two dose levels (100 and 200 mg/kg, oral) in rats against ethanol induced gastric ulcer and indomethacin indued gastric ulcer. Omeprazole and pantoprazole were used as a standard drug. In these models the parameters determined were ulcer index and % protection, pH and total acidity. The extract (100 and 200 mg/kg) showed the significant (P<0.01) reduction in ulcer index and % protection as compared to control. It can be concluded that A. oppositifolia possess anti ulcerogenic property due to the presence of flavonoids which can scavenge free radicals responsible of ulcer induction....
Investigation on preliminary phytochemical and in-vitro anti cancer activity of leaves of Delonix regia by MTT assay on Hela–Human cervix and HT-29-Human Colorectal Adenocarcinoma. The powdered leaves were subjected for the proximate analysis in which studies were carried out related to ash values, extractive values, fluorescence analysis and preliminary phytochemical screening. Major extraction was carried out by simple maceration method using ethanol as solvent. The in-vitro anti-cancer activity of leaves Delonix regia was evaluated in-vitro by MTT assay on Hela-Human cervix and HT-29-Human colorectal adenocarcinoma. A greenish solid matter of 4.53 % w/w was obtained from the dried leaves powder. Administration of ethanolic extract of Delonix regia leaves produced a significant anti-cancer activity and the IC50 value was found to be 95.11 μg/ml for HeLa cell and 73.09 μg/ml for HT-29 cell lines. In conclusion, administration of ethanolic extract of Delonix regia leaves produced a significant anti-cancer activity and IC50 value was found to be 95.11 μg/ml for HeLa cell and 73.09 μg/ml for HT-29 cell lines. The present work justifying the folklore claim of the Delonix regia leaves for treatment of different types of cancer....
Hypothyroidism is a common endocrine disorder resulting from deficiency of thyroid hormone more rarely, from their impaired activity at tissue level. Deficiency of hormone has a wide range of effects, because all metabolically active cells require thyroid hormone. The clinical features of hypothyroidism are dependent on factors like age, disease condition and the rate at which hypothyroidism develops. Methimazole is an anti-thyroid drug belongs to the class of thioamide class used for induction of hypothyroidism. Commiphora mukul is the plant that is native to India and has important therapeutic properties in ancient Indian ayurveda system. Wistar rats of either sex were divided into following four groups (n=6). Group 1: Normal control animals received 1% CMC, 20 mg/kg p.o. Group 2: Disease control animals received methimazole 20 mg/kg p.o. dissolved in 1% CMC, Group 3: Low dose animals received Commiphora mukul (LDCM) (100 mg/kg) + methimazole (20 mg/kg) p.o. Group 4: High dose animals received Commiphora mukul (HDCM) (400 mg/kg) + methimazole (20 mg/kg) p.o. All the animals were treated for a period of 30 days. Treatment with methimazole for 30 days continuously increased MDA, TSH, triglycerides, total cholesterol and decreasedT3 and T4 levels in blood. Treatment with low and high doses of Commiphora mukul have decreased MDA, TSH, triglycerides and total cholesterol, increased T3 and T4 levels restoring them to normal. Treatment with low and high doses of Commiphora mukul restored histo architecture of thyroid gland. These results suggest that, Commiphora mukul possesses protective effect in methimazole induced hypothyroidism. This effect may be attributed to its major chemical compositions like terpenoids, steroids, flavonoids, guggultetrols, lignans, sugars, amino acids and guggulsterones...
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